Wednesday, September 3, 2014

Are we getting closer to a CURE for Multiple Sclerosis?

These last two articles that have come out have been very exciting and add lots of hope for those living with MS. 



\Multiple sclerosis could be 'switched off' by retraining immune system

Scientists believe they are close to developing a drug which could 'switch off' autoimmune diseases like Multiple sclerosis by training the body to stop attacking itself

Scientists believe that regular injections could retrain the immune system and 'switch off' autoimmune diseases
Scientists believe that regular injections could retrain the immune system and 'switch off' autoimmune diseases Photo: Simon Belcher/ Alamy


Scientists believe they have discovered a way to ‘switch off’ autoimmune diseases like multiple sclerosis or Type 1 diabetes by retraining the immune system.
Autoimmune diseases are so debilitating because they trick the body into attacking itself.
But a team at Bristol University has shown that the immune system can be taught to stop treating harmless everyday proteins as if they were dangerous invaders.
In Multiple sclerosis (MS) the immune system attacks the myelin sheaths which protect nerve fibres.
The nerves carry messages to and from the brain and if they are disrupted it leads to a host or problems such as loss of mobility, vision impairment and fatigue.

However by synthesising proteins from the sheaths in a lab, and then injecting them into the blood stream at increasing doses, the body begins to learn that they are safe.
This type of therapy has already been used for allergies in a treatment known as ‘allgergic desensitisation’ but it’s only recently that scientists have thought that it could be useful elsewhere.
Researchers at the University of Bristol, said the ‘important breakthrough’ could improve the lives of millions of people who are suffering from a range of diseases.
First author Dr Bronwen Burton said: “The immune system works by recognising antigens which could cause infection.
“In allergies the immune system mounts a response to something like pollen or nuts because it wrongly believes they will harm the body.
“But in autoimmune diseases the immune systems sees little protein fragments in your own tissue as foreign invaders and starts attacking them.
“What we have found is that by synthesising those proteins in a soluble form we can desensitise the immune system by giving an escalating dose.”
The team hope that the breakthrough could lead to the development of immunotherapies for individual conditions, based on the protein or antigen that the body is responding too.
As well as MS, conditions which could be ‘switched off’ include Type 1 diabetes, Graves' disease and systemic lupus erythematosus.
MS alone affects around 100,000 people in the UK and 2.5 million people worldwide.
Professor David Wraith, of the university's School of Cellular and Molecular Medicine, said the research opened up ‘exciting new opportunities.’
"These findings have important implications for the many patients suffering from autoimmune conditions that are currently difficult to treat,” he added.
The goal is to reinstate ‘self-tolerance’, where an individual's immune system ignores its own tissues while remaining fully armed to protect against infection.
Currently autoimmune diseases are treated with drugs which suppress the immune system but they are associated with side effects such as infections, development of tumours and disruption of natural regulatory mechanisms.
The treatment is currently undergoing clinical development through biotechnology company Apitope, a spin-out from the University of Bristol, where it is being trialled in humans.
The breakthrough was welcomed by charities who said it offerd a ‘low risk’ alternative to current treatments.
“This is a really interesting and encouraging study, and adds to our understanding of how scientists might be able to alter the way the immune system responds in people with MS,” said Nick Rijke, Executive Director of Policy & Research at the MS Society
The research was published in the journal Nature Communications

Second Article:


New Multiple Sclerosis Drug May Repair Nerve Demyelination










As researchers continue to develop a clearer understanding of the underlying causes of multiple sclerosis (MS), it is becoming increasingly apparent that the future of treating the disease is likely to center on neural protection and a reversal of the demyelination process that strips away the critical insulation surrounding denuded axons. To this end, there is currently a series of studies underway for a potential, new treatment option for MS that would directly address the need for protecting neurons so that remyelination may commence, thus leading to a slowing of the disease progression and improvement of symptoms.
Recent phase I clinical trials of a novel, experimental MS therapy based on the facilitating the remyelination process has thus far revealed positive safety and tolerance findings, which are now available in Neurology Neuroimmunology & Neuroinflammation‘s August 27, 2014 issue. This new journal published by the American Academy of Neurology is free to access and is exclusively available online.
According to previously completed studies involving animal models, this new multiple sclerosis drug called anti-LINGO-1, or BIIB033, has the potential to reverse nerve demyelination. LINGO-1 is described as a ”human anti-Nogo receptor interacting protein-1 monoclonal antibody,” according to the study, and this subsequent series of phase I trials using LINGO-1 was the first to test the new formulation on human subjects. Because anti-LINGO-1 is designed to block a protein in the central nervous system that hinders myelination, this medication may accomplish what currently available MS treatments have yet to offer, which is to actually repair neurological damage.
According to the researchers, LINGO-1 is considered an emerging therapy for myelin regeneration due to the fact that it ultimately has shows to lead to “in vivo remyelination through induction of OPC differentiation and neuroprotection” in experimental immune as well as non-immune models of demyelination. Combined with a human monoclonal version of an anti-LINGO-1 antibody, which has already been developed by researchers and currently is being tested in a phase-II clinical trial as a therapy for the disease, this development, together with an increased understanding of the role that LINGO-1 plays in the myelination process, is considered by the researchers to be the impetus for a potential breakthrough, pending the outcome of current and future trials.
The published phase I clinical trial results involved 72 participants without MS, and 47 patients diagnosed with either relapsing-remitting MS, or secondary progressive MS. The researchers administered either the anti-LINGO-1 or a placebo via IV to the two groups, with the healthy group receiving one dose, and the MS group receiving two doses, two weeks apart. All of the participants from both groups were administered different concentrations of the medication, varying from 0.1 mg/kg to 100 mg/kg.
As to observable side effects of the medication, there was no significant difference between those who were on the medication and those who were on the placebo. Any observed side effects were minor and not necessarily associated with the primary indication of the drug, such as headaches, and infections of the upper respiratory and urinary tracts. There were no incidences of adverse effects or deaths, nor were there notable alterations in participants’ vital signs, EKG readings, or other safety parameters.
Those who received at least 10mg/kg of the drug retained blood concentrations comparable to those previously observed in rats that showed 90% remyelination from the drug.
The study’s author, Dr. Diego Cadavid of Cambridge, Massachusetts’ Biogen Idec, is pleased with the phase I results and has already begun work on phase II, to test if anti-LINGO-1 can restore myelination along with physical and cognitive function.

This is an exciting time for research and MS! Let's hope we are on to something so all of us that have Multiple Sclerosis including myself and turn it off and be CURED! We could potentially all say we used to have MS. What a wonderful feeling! 

What are your thoughts? Will we see a cure for MS in our lifetime? Or even in the next 5 years?



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Thursday, August 14, 2014

THE 5 MOST COMMON MISCONCEPTIONS MADE ABOUT SHAKEOLOGY


THE 5 MOST COMMON MISCONCEPTIONS

MADE ABOUT SHAKEOLOGY


#1 MISCONCEPTION:
Shakeology is a protein shake.
Meaning that it is just a shake that provides extra protein. I can't blame the general public for
thinking this, since "protein shake" has nearly become an interchangeable term for ANY shake.
But all shakes are not created equal—especially ones that contain superfoods. Shakeology is a
very nutrient-dense shake that can be used for breakfast, lunch, or dinner. You'd have to eat a
whole lot of fruits and vegetables to equal the nutrition in a single glass of Shakeology—and you
probably couldn't do it for less than 170 calories. Shakeology makes it very easy to cut your
calories, without substantially cutting down your daily volume of nutrients needed. Truth be
told, the majority of people are WAY MORE nutrient deficient, than they are protein deficient.
So why just stop at a protein shake?

#2 MISCONCEPTION:
Shakeology is about comparing carbs, proteins, and fats to other shakes.
This is not at all what you should be comparing when you look at other shakes versus
Shakeology. Sure, other shakes have 0 grams of sugar. But how do you think those shakes
achieve that? Hint, it's not natural. Yes, that's right, they are probably using ARTIFICIAL
sweeteners to get to 0 grams of sugar. Even fruit has sugar in it. A shake with 0 grams of sugar is
using ARTIFICIAL sweeteners. Shakeology has NO artificial sweeteners, NO artificial colors, NO
soy, NO artificial stimulants, and NO artificial flavors. One of its main sweeteners is Stevia,
which is plant-based.

#3 MISCONCEPTION:
Shakeology is just a bunch of extracts, with no whole-food ingredients. That's not true.
Whenever it's possible and sustainable for the formula, the superfoods in Shakeology are
preserved in their whole-food state to retain maximum nutrient value. It's very difficult to use
whole, plant-based ingredients while also making sure the formula retains as much nutritional
value as possible. Shakeology has a whole team of food scientists whose mission is to maximize
the nutrition in every ingredient in Shakeology. Imagine trying to juice all those superfoods!
Shakeology is way less expensive and a huge time-saver.

#4 MISCONCEPTION
Shakeology is EXPENSIVE.
To anyone who feels this product is expensive, then I have not done my diligence in breaking
down its REAL VALUE. Most people will agree that they would spend an average of 3 to 7
dollars on a HEALTHY, nutritious meal. I know most store-bought salads cost even more than
that, and don't contain nearly the dense concentration of nutrients. But on average I think we
can all agree, healthy meals run between $3–$7. Shakeology, at $4.33 per SHAKE, comes in on
the LOW END of average. (You can make Shakeology into a breakfast or lunch that you'd be2
buying anyway.) Not only are you spending less than you normally would, but you are also
getting vital nutrients your body needs that you just can't get from your run-of-the-mill salad—
plus the normal range of vitamins and minerals. So you can replace your VITAMINS, too. Sure,
you may need a specific vitamin, based on your conditions, geography, or age, but in general,
Shakeology will provide you with a solid base of your whole-food nutrients.
Here is my next point. When was the last time you went to your grocery store and bought
THIRTY meals all at once? Typically, I'm guessing, you buy a few days' worth each time. When
you buy a bulk bag of Shakeology, you are buying 30 of your shakes up front. That means you'll
spend less money at the grocery store. Because of the grocery savings, I actually deduct my
monthly Shakeology from my grocery budget. For the price, I cannot duplicate its vast quality of
ingredients and nutrients.

#5 MISCONCEPTION:
Shakeology is only for WEIGHT LOSS.
Most shakes are marketed this way. But here's the thing. Anything will induce weight loss if it's
low enough in calories. Just because you are drinking a shake, does not mean the fat will melt
off. Actually, if you are not getting enough nutrients and calories you will actually inhibit your
weight-loss efforts. Shakeology is about HEALTH. When you put the RIGHT nutrients in your
body that it needs to develop, heal, recover, repair, and thrive, you may ultimately have MORE
energy, LESS cravings, and FEEL better, and therefore, you eat less and become more active.
With Shakeology, weight loss becomes a BY-PRODUCT of dense nutrition. To make my point,
when was the last time you dieted and cut calories only to feel tired, grouchy, and have a ton of
cravings? That is because you may have been nutrient deficient. What if you're at your goal
weight or need to GAIN weight? Because Shakeology is about DENSE NUTRITION, you can use it
as your base and add clean calories to make it 300 calories or more. Not everyone needs to lose
weight, but everyone needs to be healthier. Shakeology isn't MAGIC. It's just clean, dense
nutrition made SUPER-easy for everyone at a very affordable price. It's my family's "fast food"
on the counter. Yes, my family goes through 4–5 bags a MONTH because, even though we all
have different weight and caloric needs, we all share the same NUTRITIONAL needs. Shakeology

isn't a weight loss shake—it's a nutrition shake.

www.shakeology.com/karenkrueger or message me for details on discounts and learn more about my free services :)

Wednesday, July 16, 2014

I am absolutely loving my new workout PiYo!! It is so fun and helps me stay strong and flexible without hurting myself!  Check out my latest workout Full Body Blast below! I love the slides it comes with! Just another way to get stronger and have even BETTER results! I am currently running an awesome exclusive test group and will be starting another July 28th. If you are interested contact me through Facebook it is the best and easiest way to reach me. Plus that is where our private support groups are. I look forward to working with you!

If you just want to order this on your own click here PiYo Challenge Pack either way I hope you will reach out to me as I love to help others reach their health and fitness goals!


Sunday, June 29, 2014

What to Expect from the 3-Day Refresh Program


What to Expect from the 3-Day Refresh Program

http://bit.ly/3cleanseday


Like you might know from my Facebook and Twitter feed, I’m starting a new group on Monday for the 3-Day Refresh. This is a great Beachbody program and it will guarantee to kick start anyone’s weight loss. Because of the challenge, I wanted to tell you all a little bit about what the 3-Day Refresh challenge is all about and the positives of doing such a body cleanse every once in a while.

What is Included in 3-Day Clean Challenge

The 3-Day Refresh program by Beachbody is an amazing way to get your body fully cleansed and to start your healthier eating habits. It is very effective, as short cleanse programs usually are, and you are guaranteed to feel a lot better afterwards. The great thing about this program is that it focuses on keeping your body strong during the challenge. A number of other cleansing diets can easily get you feeling down and out of energy, but the Shakeology shakes in this one won’t let you down.

The kit includes:

6 x Shakeology packets in a flavor of your choice– these are packed with green vegetables and berries to guarantee you start your day with the right nutrition.
6 x Vanilla Fresh shake – this high-protein shake is perfect for lunch and dinner providing you a lot of nutrients to go about your day.
3 x Fiber Sweep fiber is the best way to clean your stomach daily and these Fiber Sweepers will naturally cleanse your stomach giving it a fresh start.


To order the challenge pack click here http://bit.ly/3cleanseday

http://bit.ly/3cleanseday
 

Why Try a 3-Day Cleanse?

All these short-burst cleanse programs have been around for a long time. There are still plenty of skeptics who think they aren’t a healthy and a good way to start your weight loss, but these people are wrong about this.

Cleansing your body and your gut every once in a while is essential for staying healthy. If you feel like your skin has lost its radiance and you are constantly tired, then you might just have unhealthy amounts of ‘junk’ stuck in your gut. If you go through a three day cleanse you can get your gut cleared and your body will start soaking in all the nutrients and vitamins from your food a lot quicker again.

A very recent study by the University of Southern California found that short bursts of fasting could also help your body trigger stem cell regeneration. If you are going through cancer treatments or you suffer from other cell-level diseases, these little cleansing breaks every once in a while can be highly beneficial for you.

All in all, by restricting your body to the healthy shakes provided by the 3-Day Refresh program you can restart your body’s immune system and create a stronger healthier body. And since the Shakeology drinks have over 20 essential vitamins and nutrients included, you won’t feel bad during the three-day cycle.

Furthermore, if you are looking to get rid of your body fat, then you can truly kick-start it with fasting in this way. There is plenty of evidence to suggest that when you are eating less for three days, your body starts to burn off fat a lot quicker. Instead of needing to eat constantly, your body starts using all the excess fat as a fuel. This naturally helps you lose weight quicker and ensures you don’t feel out of energy.
The 3-Day Refresh program is such an efficient and fun way to start your weight loss that I highly recommend it to anyone! I can’t wait to see the results of my group’s progress during this challenge! Feel free to contact me if you want to know more about my fitness and weight loss challenges.


Links:





Wednesday, June 11, 2014

Be the first to find out when PiYo™ is available! Plus, be entered to win a FREE PiYo™ Workout.*

Chalene Johnson took the very best Pilates and yoga-inspired moves and cranked up the speed to give you full throttle cardio, strength, and flexibility training - all at once. PiYo packs it ALL into each workout so you can build lean muscle mass - as you're burning crazy calories.

*Once PiYo™ is released, we will do a drawing that month where you have the chance to win your choice of either the PiYo™, P90X®, or Insanity® Workout. Only one workout program will be given away.
http://karenkrueger.automaticceo.com/go8
I will be having a huge PiYo challenge group for those who are on my facebook and make me their coach and order the program through me. It is going to be so much fun. If you are interested please add me on facebook. And make me your coach :) Thank you

If you want strength and flexibility and to work on your balance and even cardio then PiYo is for you :) I am so excited for this program to be available on June 19th. I even got PiYo Certified because I love the program so much and wanted to learn all I could about it to help anyone who made me their personal coach and joined my challenge group :)

8 more days until the release of this amazing program!


http://karenkrueger.automaticceo.com/go8


Tuesday, March 18, 2014

Can you help me?

Hi Everyone!!!!

It has been a while since I updated this blog. But things are going great.

I am still following the Dr. Wahls Diet and working out daily as well as drinking vegan chocolate shakeology.

All of it together is helping me soo much.


This year I'm participating in the Nancy Davis Foundation Virtual Race to Erase MS to help erase multiple sclerosis. Please consider sponsoring me with a donation so that the Race to Erase MS can continue in their quest to find a cure for this debilitating disease!

Hundreds of thousands of people across the country have MS and people are diagnosed with this incurable disease everyday. There are an estimated 400,000 people in the US alone who have been diagnosed with MS. These people are our friends, our family members, or neighbors and our coworkers. Organizations like the Race to Erase MS and those they partner with are on the frontlines helping those with MS and raising awareness for this disease.

Please consider making a donation today. No amount is too small, and whatever you can give will be greatly appreciated. Please help me raise awareness for this cause and raise vital funds for MS research so within the next few years we can find a cure multiple sclerosis, and people will no longer have to live with this disease.

Thank you!

Follow This Link http://virtualrace.kintera.org/faf/donorReg/donorPledge.asp?ievent=1079937&lis=1&kntae1079937=D77640A7ECA340C58C6493D0FB58447B&supId=403079826&emaillogid=7596536624 to visit my personal web page and help me in my efforts to support Nancy Davis Foundation For Multiple Sclerosis


I am excited to be supporting such an amazing organization!